Applications
Applications - Chromatography
Clinical Assay for EtG and EtS Metabolites - Customized Chromatography
Standard detection methods for alcohol abuse by headspace GC-FID are only reliable for 6-24 hours after ingestion due to the body's normal metabolic process. Monitoring of the ethanol metabolites ethyl glucuronide (EtG) and ethyl sulfate (EtS) from urine can extend the detection window up to 80 hours after exposure. Analysis of these metabolites can be challenging due to their polar nature and difficult matrices, requiring a lengthy method development step. more
Why Ultrapure Water is Important for Nano-LC/MS Applications
Nano-flow LC (nano-LC) is an important tool in proteomics research and in the measurement of low level biomarkers. To avoid the common problem of emitter clogging, only the highest purity solvents and reagents should be used. more29.11.2011Simplified and Reproducible Separation of Ethyl Sulfate Impurity in Indinavir Sulfate
Thermo Fisher Scientific announced a new method that uses ion chromatography (IC) to separate ethyl sulfate in an indinavir sulfate drug sample. Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS. more
Modern Detection Systems in Ion Chromatography
This article describes the use of combined ion chromatography-mass spectrometry (IC-MS) and ion chromatography-inductively coupled plasma mass spectrometry (IC-ICP-MS) to analyze potentially harmful compounds in the environment. more
Ultra Performance Supercritical Fluid Chromatography (UPSFC)
Supercritical fluid chromatography (SFC) is a chromatographic technique that employs a supercritical fluid, most commonly CO2, combined with organic co-solvents, such as methanol and ethanol, as the mobile phase. The low viscosity and high diffusivity of supercritical fluids offers fast separations with high chromatographic efficiency.Introduction
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Evaluation of the Separation of Acidic Compounds
Hydrophilic interaction chromatography (HILIC) [1] has been described as a useful alternative to reversed-phase chromatography for polar compounds that not are retained on conventional C18 columns. In the HILIC mode of separation, a mixture of organic and aqueous solvents are used as mobile phase in combination with polar stationary phases [2-4], such as ion exchange, amino, silica, diol, zwitterion to obtain retention of highly polar compounds. Silica columns intended for HILIC are commercially available and provided by several manufacturers. more
Curse of the Pharaohs?
Were mycotoxins to blame for a mysterious series of deaths after opening the tomb of the Egyptian Pharaoh Tutankhamun? Many books and theories circulate on the possible cause, and science is still divided on this issue. One thing is certain: fungal toxins (mycotoxins) are everywhere: in the air, in foods - in minimal concentrations. Their toxicity is, however, mostly underestimated. Allergies and breathing difficulties are just some of the reactions described, even at apparently low mycotoxin concentrations. more
Ultra-High LC Performance for all Users
For decades, HPLC has been one of the most important techniques available to analytical chemists. However, despite the maturity of the technique, there continues to be a great deal of scientific research in improving selectivity and efficiency, and in providing the maximum analytical information in the shortest time possible. more
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