Applications
You are here: Home › Applications Overview › Analytical Instruments › Spectroscopy & Elemental Analysis
Applications - Spectroscopy & Elemental Analysis
IC-ICP/MS Analysis: Gadolinium-based MRI Contrast Agents
The use of contrast agents in non-invasive diagnostics provides a specific and high-detailed picture of organs and makes it possible to differentiate between healthy and diseased tissue. Whilst radiocontrast agents (RCA) change the X-ray absorption of the radiographed organ relative to its surrounding tissue, contrast agents for magnetic resonance imaging (MRI) are based on the use of magnetic fields caused by charged elementary particles such as protons and electrons. Compared to traditional X-ray imaging, MRI uses no ionizing radiation. more
Challenges in Quantitative Bioanalysis
High selectivity is a key component of successful quantitative bioanalysis. The ever increasing sensitivity and throughput requirements of bioanalytical assays often pose method development challenges. A new technology in ion mobility brings the power of differential ion mobility separation to complex mass spectrometric bioanalysis. more
Total Organic Carbon Analysis
Shimadzu's new TOC-L Series covers TOC analysis in a wide range of applications. The analyzers combine combustion catalytic oxidation at 680°C with NDIR detection method. The ISP sample pretreatment module is a key component of the TOC-L instrument. The measuring range for TC determination has been increased to 30,000 mg/L. more
TOF-MS for Fast GC and GCxGC
Nowadays in the analytical field, demands in terms of analysis speed and higher separation power are continuously increasing. These trends have been successfully addressed in Gas Chromatography (GC) in the last decades, through continuous developments in both Fast GC and comprehensive two-dimensional GC (GCxGC). However, when positive identifications are required, Time of Flight Mass Spectrometry (TOF-MS) is the technology capable of providing high speed acquisition rate to collect sufficient information for reliable peak reconstruction. more
Infrared Spectroscopy with Nanoscale Resolution
IR spectroscopy has been widely used in the characterization of countless materials. However, spatial resolution has been restricted by the diffraction limit. In practical terms, transmission FT-IR was restricted to about three times the wavelength of the IR radiation and even ATR will only achieve resolution approaching the wavelength. more
Tissue Imaging Mass Spectrometry
Mass spectrometry (MS) permits to read out molecular information from tissue samples (fig. 1) such as patient biopsies. Using MALDI-TOF MS, even molecular images from histological sections can be generated at an image resolution today that approaches the single cell level. New technologies are the foundation for the use of MALDI Imaging MS (IMS) in many applications including biomedical and clinical research. High definition molecular imaging of proteins in tissue sections can significantly contribute to the understanding of biological processes. more
The Evolution of Ion Trap Mass Spectrometry
Quadrupole ion trap mass spectrometers, commonly called "ion traps", have a long, rich history as extremely sensitive analytical instruments that identify compounds and their molecular structure based on their molecular weight. The capability to accumulate and manipulate ions in time and subsequently perform selective mass ejection to an external electron multiplier gives ion traps unique abilities and attributes. more
Absorbance Based Assays
The advancement of microplate reading technology has shown that multidetection readers are the best choice when it comes to using a single reader for a variety of proven biochemical and cell based assays. more
- Legal
- Help
- Participate
- Related Publications