Applications
Next-generation Sequencing - Application in Molecular Diagnostics
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(pdf-file 652.84 KB)Next-generation sequencing (NGS) has developed over the past five years into a valuable tool for research applications in the fields of genomics, transcriptomics and epigenomics. Research projects often rely on the analysis of the entire genome. For diagnostic purposes, however, sequencing of the entire human genome is not required and is not even desirable. As a result, an upstream technology known as "target enrichment" has been used for roughly the past two years to selectively resequence specific regions of the genome. Combining target enrichment with NGS will improve researchers' ability to analyze sections of the genome relevant to disease. Making use of the enormous data output, scientists are able to analyze multiple genes from different patients simultaneously and in a single run.
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Keywords : 454 Life Sciences Carola Wagner Epigenome Epigenomics Genome Genome Sequencer System genomics GS FLX GS Junior Hanns-Georg Klein IMGM Laboratories Kaimo Hirv Molecular Diagnostics Next-generation sequencing NGS research applications tool Roche Stefan Kotschote Transcriptomics
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