X-ray crystallography is a crucial research technique for chemists who would like to investigate the structure of their compounds in solid state.
So far lots of Nobel prizes have been awarded for research fundamental to or applying crystallographic methods, from the early discoveries of Röntgen until the recent prizes for research on quasicrystals or implementation of theoretical methods in the refinement of macromolecules. Nevertheless, the field still undergoes a rapid development and more breakthroughs are expected, in particular in the field of X-ray free electron laser (XFEL) crystallography.
X-ray crystallography is the most widely applied experimental method for biomolecular structure determination and is routinely used to ascertain how a pharmaceutical drug interacts with its protein target. However, a recent study published in Nature Communications suggests that current software programs used to predict a protein's structure from X-ray crystallography data dramatically underestimate the level of protein dynamics and do not give a realistic picture of the protein's structural heterogeneity.
With X-rays from DESY's light source PETRA III, Danish scientists observed the growth of nanoparticles live. The study shows how tungsten oxide nanoparticles are forming from solution. These particles are used for example for smart windows, which become opaque at the flick of a switch, and they are also used in particular solar cells. The team around lead author Dr.
The "Horizons in Molecular Biology" symposium series aims at giving young researchers the opportunity of face to face contact with leading scientists in a stimulating cross-disciplinary environment.
Anthrax is a dangerous infectious disease caused by the spore-forming bacterium Bacillus anthracis and transmitted by infected farm animals. For several years now, anthrax has also been feared as a biological weapon. Attacks with spore-containing letters caused five deaths in 2001.
Anti-HIV compounds inhibit the activity of human immunodeficiency virus (HIV), the virus that causes AIDS. Scientists at The Scripps Research Institute have used a powerful new chemical-screening method to find two new promising compounds.
EMBL: In this video (click here), a protein called myomesin does its impression of Mr. Fantastic, the leader of the Fantastic Four of comic book fame, who performed incredible feats by stretching his body.
Bruker, a provider of high-performance scientific instruments for molecular and materials research, as well as for industrial, clinical and applied analysis, celebrated the grand opening of its new Singapore Center of Excellence.
Photosynthesis is the most essential process for most forms of life on Earth. A research team led by biochemist Prof. Michael Groll (Technical University Munich) and biologist Dr. Bettina Bölter (Ludwig-Maximilians-Universität Munich) has now shown how an interaction between two proteins helps plants control the rate of photosynthesis and carbon dioxide fixation in accordance with changes in light intensity. They report their findings in the online edition of PNAS.
In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs. The findings may lead to the development of new therapies to treat inflammation, wounds, asthma, and malignant tumors. The results of the two companion studies were published in the September 3, 2010 issue of the prestigious journal Science.