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Salt-tolerant Membrane Adsorbers
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Sartorius Stedim Biotech introduced Sartobind Stic PA (primary amine). Polishing in antibody production is usually performed on quaternary ammonium (Q) membranes in flow-through mode, since the overall speed and productivity are much higher than on traditional anion-exchange columns. However, the binding capacity of Q ligands is reduced at higher conductivities, so concentrated feed streams must be diluted to adequately remove contaminants such as DNA, host cell proteins, viruses and endotoxins.
The Company's anion-exchange membrane overcomes this limitation and binds contaminants at high conductivities under high-salt conditions at up to 20 mS/cm. The salt-tolerant anion exchanger can directly process cation-exchange pools without further dilution. Buffer consumption and buffer tank investments can be All membrane adsorber capsules are "plug and play" devices and can be used like filters. As the materials are disposed of after a single use, this saves validation costs.
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Keywords : anion exchange Biochemistry Bioprocess Biotechnology Columns Life Science Sartobind Stic PA Sartorius Stedim Biotech Screening Products
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Germany
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