Laboratory Journal – Business Web for Users in Science and Industry en Zeiss Continues Growth In the past 2016/17 fiscal year (ended 30 September 2017), Zeiss increased both its revenue and earnings to a record level: revenue rose by 10 percent to EUR 5.348 billion (prior year: EUR 4.881 billion). At EUR 770 million, earnings before interest and tax (EBIT) were significantly above the already high level of the previous year (615 million). The EBIT margin has increased to over 14 percent. Order intake grew by a healthy 12 percent and is now at EUR 5.625 billion, underscoring the growth ambitions of the technology company. Wed, 13 Dec 2017 13:40:00 +0000 Genome Fidelity and its Consequences for Cellular Health Non-inherited, chance mutations may also provide a new window into understanding human disease. It’s biology’s version of the whisper game.  Inside a cell, every DNA phrase or sentence that makes a protein, known as a gene, first must be precisely copied, to ensure its instructions can properly build the foundation of life. But much like children tasked in the game with faithfully whispering a phrase to one another, each time, there is the possibility of introducing errors when the DNA information is passed along inside every living cell. Wed, 13 Dec 2017 12:29:00 +0000 IXplore Solutions-Based Microscopy – Because your Science Matters Discover the Olympus IXplore inverted imaging platform, specifically designed for applications. Being able to focus on the important things drives advances in science, and research relies on innovative tools to enable this. That’s why Olympus has developed a range of IXplore microscopy solutions exactly tailored to specific research needs. Wed, 13 Dec 2017 12:01:00 +0000 Lauda With a New Logo Lauda is a global leader in precision temperature control in medical technology, material testing, biotechnology, laboratories, research, and production. A new corporate design is intended to portray the uncompromising quality and comprehensive expertise of Lauda all over the world. The company image has been completely overhauled by Munich branding agency Martin et Karczinski adequately to represent their market position, reinforced by outstanding innovation. Tue, 12 Dec 2017 14:12:00 +0000 Nano-Generators A team of University of Alberta engineers developed a new way to produce electrical power that can charge handheld devices or sensors that monitor anything from pipelines to medical implants. The discovery sets a new world standard in devices called triboelectric nanogenerators by producing a high-density DC current – a vast improvement over low-quality AC currents produced by other research teams. Tue, 12 Dec 2017 08:26:00 +0000 3-D Printed Metals A new technique by which to 3D print metals, involving a widely used stainless steel, has been show to achieve exception levels of both strength and ductility, when compared to counterparts from more conventional processes. Mon, 11 Dec 2017 11:55:00 +0000 One X-ray Measurement, Three Kinds of Information Whatever the size of mobile phones or computers are, the way in which such electronic devices operate relies on the interaction between various materials. For this reason, engineers as well as researchers need to know exactly how specific chemical elements inside a computer chip or a transistor diode behave, and what happens when these elements bond. Mon, 11 Dec 2017 08:35:00 +0000 Genotoxicity A new biomarker test developed by researchers at Georgetown Lombardi Comprehensive Cancer Center and their colleagues can help predict, with up to 90 percent certainty, which chemical compounds can cause DNA damage that could lead to cancer. Tue, 05 Dec 2017 14:08:00 +0000 Nanomaterials in Environmental Samples In textiles, cosmetics, food and food supplements, washing agents or as coatings of kitchenware nanomaterials (NM) are processed. The numerous potential applications and the continuously rising volume of synthetic NM illustrate the increasing exposure of human and environment with synthetic NM. Due to a lack in measurement technologies for determining the continuity and intensity of NM exposure of humans, concrete data is missing for assessing the NM exposure and the risk potential. Methods Thu, 30 Nov 2017 09:42:00 +0000 The injection, the unknown and complex being Miniaturization in chromatography also requires a corresponding reduction of the injection volume. Whereas several microliters can be injected on columns with an inner diameter (i.d.) between 2.1 and 4.6 mm, such high volumes can lead to a dramatic loss of the separation efficiency for micro- or nano-LC columns. The following article therefore presents the technical concepts that exist for miniaturized HPLC systems to keep the injection volume as low as needed. Thu, 30 Nov 2017 07:54:00 +0000 One-Way Ticket for a Ride While modern society is inventing new ways to rid the body of accumulated toxins, ranging from detoxifying foods and drinks to sweating in the hot Finnish sauna, our body has already evolved its own spa, which cleans up the cells by breaking down and removing the damaged proteins and organelles. This process is called “autophagy” or “self-eating” and was discovered in the 1990s by the Japanese cell biologist Yohinori Ohsumi, who was the first to study the mechanism of autophagy and to identify the genes for this recycling process in cells. Thu, 30 Nov 2017 07:03:00 +0000 Cheat Sheet: Polymerase Chain Reaction (PCR) II For those utilizing PCR in everyday applications, primer design could seem like yesterday’s news. However, we still believe reviewing good primer design guidelines is helpful to any researcher involved in genetic research. The G.I.T. Laboratory Cheat Sheet "Polymerase Chain Reaction (PCR) II" provides you with information on the following topics: Wed, 29 Nov 2017 09:50:00 +0000 Increasing the Survival Rate of Manipulated Cells The investigation of living cells is of high relevance in the biosciences. To observe intracellular structures of living cells, specialized tools in combination with fluorescent probes can be used, which grant access to their complex machinery. A possible strategy to investigate these intracellular structures of single living cells is to combine specialized tools with functionalized fluorescent probes. These tools overcome the plasma membrane of a living cell by penetration with pipettes or cantilevers to deliver the fluorescent probes. Wed, 29 Nov 2017 08:46:00 +0000 Screening for Therapeutics against Untreatable Mitochondrial Disorders Mitochondrial DNA (mtDNA) mutations cause untreatable disorders affecting the nervous system. These diseases suffer from a lack of viable modeling tools due to the challenges associated with mtDNA engineering. We recently showed that neural progenitor cells (NPCs) differentiated from patient-derived induced pluripotent stem cells (iPSCs) can be used to model mtDNA disorders and to set up phenotypic compound screenings. This strategy opens the way to the discovery of novel therapeutics against these so far untreatable human diseases. Wed, 29 Nov 2017 08:04:00 +0000 Quantum Computing A team at the University of Sydney and Microsoft, in collaboration with Stanford University in the US, has miniaturised a component that is essential for the scale-up of quantum computing. The work constitutes the first practical application of a new phase of matter, first discovered in 2006, the so-called topological insulators. Tue, 28 Nov 2017 14:43:00 +0000 Photoinduced Demagnetization and Insulator-to-Metal Transition Magnetic Dynamics of Ferromagnetic Insulating BaFeO3 Thin Films Tue, 28 Nov 2017 10:09:00 +0000 Migraines Linked to High Sodium Levels in Cerebrospinal Fluid Migraine sufferers have significantly higher sodium concentrations in their cerebrospinal fluid than people without the condition, according to the first study to use a technique called sodium MRI to look at migraine patients. Tue, 28 Nov 2017 10:04:00 +0000 The Wonder Material Graphene Graphene is a two-dimensional honeycomb lattice of carbon atoms (fig. 1a) – only one monolayer of graphite. Yet this single layer has caused quite a stir due to its extraordinary properties: graphene conducts better than copper, shows exceptional mechanical strength and elasticity, and exhibits quantum effects already at room temperature. Tue, 28 Nov 2017 08:12:00 +0000 Röntgen Award Winner 2018 The Justus Liebig University Giessen is awarding its Röntgen Prize this year to PD Dr. med. Daniela Münzel. The Röntgen Prize is awarded each year at an academic award ceremony at the Justus Liebig University Giessen for outstanding work on basic research into radiation physics and radiation biology. Mon, 27 Nov 2017 15:59:00 +0000 Chlorine - Disinfectant in the Water Industry Water is susceptible to impurities and contamination with pathogenic germs, and Chlorine is still the most important disinfectant for basin water and, in some countries and in certain events, for drinking water too. Which legal regulations have to be observed and which photometric test kits for Chlorine are available? Mon, 27 Nov 2017 14:51:00 +0000 Read & Win: Practical Laboratory Automation Practical Laboratory Automation is a topic that is gaining more and more importance, as laboratories are moving towards becoming more digital and interconnected. The author of this book bridges the gap between programmer's references and theoretical books about Laboratory Automation. The approach is hands-on, giving the readers expemplary real-world problems and providing them with the necessary knowledge to solve them using AutoIt. The software used is freeware and can also be used to automate processes within the Windows OS. Mon, 27 Nov 2017 08:25:00 +0000 Molecular Wires Soluble and processible inorganic or organometallic polymeric structures comprising a linear backbone of metal atoms are uncommon. Different types of related compounds have been studied, which differ in the interactions between the metal atoms (Fig. 1). Thus, polymeric structures were established by covalent metal-metal bonds, by electrostatic attraction of oppositely charged coordination units (resulting in weak interactions between adjacent metal atoms) and by bidentate ligands connecting neighboring metal atoms (which do not interact with each other). Mon, 27 Nov 2017 07:40:00 +0000 The Application of a Shake Flask Reader in Teaching Dissolved oxygen (DO) and pH are key parameters for microbial fermentations and cell cultures. The importance of DO and pH for bioprocesses as well as methods for their measurement are taught to students in the bachelor (B. Sc. Biotechnology) and master program (M. Eng. Bioprocess Engineering). Mon, 27 Nov 2017 06:59:00 +0000 Diamond Turning into Graphite In a surprising achievement, a team of scientists has turned diamond into graphite, using an X-ray laser. What may seem undesirable at first glance, is a decisive step forward in understanding the fundamental behaviour of solids when they absorb energetic radiation. For the first time, the researchers around Franz Tavella from SLAC National Accelerator Laboratory in the US, Sven Toleikis from DESY and Beata Ziaja from DESY and the Institute of Nuclear Physics in Krakow were able to follow the graphitization in a time-resolved manner. Fri, 24 Nov 2017 08:55:00 +0000 Batteries Phones, laptops, electric cars – batteries are everywhere. And to meet the expectations of today’s consumers, these batteries are increasin­gly lighter, more powerful and designed to last longer. Currently the core technology for these applications is lithium ion batteries. But the technology is expensive and contains a flammable liquid, which may represent a safety hazard, when the battery is abused. Thu, 23 Nov 2017 09:21:00 +0000