Laboratory Journal – Business Web for Users in Science and Industry en Cancer Cells May Streamline Their Genomes in Order to Proliferate More Easily Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA. While downsizing might enable these cells to replicate faster, it also seems to render them less able to withstand DNA damage. Fri, 23 Jun 2017 10:46:00 +0000 Do Proton Pump Inhibitors Increase Risk of Alzheimer's Disease? Proton pump inhibitors (PPIs) are medications used to treat digestive problems such as ulcers and reflux disease by reducing the body's production of the acid that helps us digest food. Ulcers are sores that develop on the lining of our digestive system; when they develop in the upper part of the small intestine they are called "duodenal ulcers." Reflux disease is a condition in which stomach acid or other fluids in the digestive system irritate our food pipe, also known as the esophagus. Fri, 23 Jun 2017 08:52:00 +0000 New Impact Factors Released If you are interested in seeing how the impact factors of the peer-reviewed journals from Wiley have changed, our colleagues from Chemistry Views have assembled the data and put it into a well-structured format. Please find all the details here. Fri, 23 Jun 2017 08:32:00 +0000 OptRF long-term testing of reagent-free measurement The wastewater treatment plant Peißenberg permitted WTW to perform long-term testing of the reagent-free measurement of COD and nitrate for a period of approx. 6 weeks. Two different WTW reagent-free measuring methods were tested: One was the IQ Sensor Net spectral sensor, the other was the new reagent-free photometry (OptRF) with the photoLab® 7600 UV-VIS. These two methods were compared to laboratory results from photometric cuvette tests. Thu, 22 Jun 2017 13:19:00 +0000 IDS goes wireless Wireless transmitter modules for full freedom of movement when measuring pH,conductivity, dissolved oxygen and turbidity with IDS sensors! Measure comfortably in confined spaces, e.g. under laboratory hoods and laminar flow benches. Thu, 22 Jun 2017 11:16:00 +0000 20 Years of Raman Imaging The Raman imaging company Witec celebrates its 20th Anniversary. It was founded in 1997 as a 3-person spin-off from the Physics Department of the University of Ulm and has grown into a company of 60 employees including the Ulm headquarters and its branch offices in Spain, China, Japan, Singapore and the USA. As reflected in the company’s maxim "Focus Innovations" Witec’s success is based on introducing new technologies and a commitment to maintaining customer satisfaction with high-quality, flexible and empowering products. Wed, 21 Jun 2017 10:24:00 +0000 REAfinity Recombinant Antibodies Miltenyi Biotec’s recombinantly engineered REAfinity Antibodies for flow cytometry are produced under standardized production processes starting from a defined DNA sequence, ensuring high purity and lot-to-lot consistency. These antibodies do not display any undesired mixtures of heavy and light immunoglobulin chains, which is often the case with conventional monoclonal antibodies. In addition, site-specific mutations eliminate non-specific binding of antibodies to Fcg receptors, thereby avoiding background signal. Tue, 20 Jun 2017 14:55:00 +0000 MACS GMP T Cell TransAct from Miltenyi Biotec MACS GMP T Cell TransAct is a ready-to-use reagent for efficient in vitro activation and expansion of human T cells. Also available in research grade. Tue, 20 Jun 2017 14:46:00 +0000 Waters Introduces LiveID Software for Real-Time, Direct-From-Sample Food Analysis and Plant Phenotyping Waters Corporation introduced its new LiveID Software for near- instantaneous, direct-from-sample measurement and classification of food products including meat and crops by Waters’ quadrupole, time-of-flight (QTof) mass spectrometers. Thu, 08 Jun 2017 12:57:00 +0000 Karl Deisseroth wins 4 million euros Fresenius Research Prize Karl Deisseroth, MD, PhD, a Stanford University professor of bioengineering and of psychiatry, has won the 2017 Fresenius Research Prize for his pioneering work in two distinct biomedical technologies — optogenetics and hydrogel-tissue chemistry — and for exploring his clinical specialty, depression, at the level of its underlying neural circuitry.  Deisseroth, who holds the D.H. Chen Professorship and is a Howard Hughes Medical Institute investigator, accepted the award today at a ceremony in Berlin. He will also give a talk, to be followed by a symposium, on June 1. Thu, 01 Jun 2017 12:35:00 +0000 Validation of X-Ray Fluorescence X-Ray Fluorescence is a powerful alternative to Inductively Coupled Plasma Optical Emission Spectrometry technique. A benchmarking of EDXRF instruments was launched to maintain awareness about their analytical performance capabilities and for allowing up-to-date recommendations to factory end-users. An EDXRF benchmarking methodology is explained with the description of the different steps, the critical points to respect in order to ensure a proper validation and the key performance criteria on which to focus. Introduction Wed, 31 May 2017 11:27:00 +0000 Detecting Weak Protein Interactions Protein-protein interactions have been implicated in cell growth, cell signaling, morphology, apoptosis, and a variety of additional cell processes. However, weak or transient protein interactions have proven difficult to study using traditional affinity purification. Exclusion-based Sample Preparation (ESP) can accelerate workflows and enable the study of weak interactions, which may reveal new targets for drug discovery. Wed, 31 May 2017 08:13:00 +0000 Multi-Parameter Flow Cytometry Man’s immune system is subjected to a daily battle against invading pathogens and degenerate cells. A finely coordinated network of cells ensures that they are recognized and destroyed as early as possible. In this context one speaks of the two arms of the immune system: the innate immune system, made up of monocytes, macrophages, natural killer cells, granulocytes, and dendritic cells, and some others, and the adaptive immune system of T cells and B cells. Wed, 31 May 2017 06:59:00 +0000 Micro-LC The Basics For some time “sustainable processes” has been the phrase on everyone’s lips. As far as analytical labs are concerned there are many possibilities for saving energy or rather for using resources more efficiently [1]. Besides the real “energy guzzlers” such as extractors and safety cabinets, complex analysis apparatus has to be subjected to critical system checks, too. Tue, 30 May 2017 13:28:00 +0000 IMAC Resin Selection Immobilized metal affinity chromatography (IMAC) is one of the most widely used affinity chromatography techniques for protein purification. It leverages the affinity of transitional metal ions such as Ni2+, Cu2+, Zn2+ and Co2+, for the amino acids histidine (His) and cysteine (Cys). To create an IMAC resin, transitional metal ions are immobilized using chelating ligands on solid supports or resin backbones. When protein samples are run on IMAC resins, His/Cys-rich proteins preferentially bind to the resin and are purified. Tue, 30 May 2017 12:19:00 +0000 Stimulating the Immune System to Fight Cancer Swiss scientists from the University of Geneva (Unige), Switzerland, and the University of Basel have created artificial viruses that can be used to target cancer. These designer viruses alert the immune system and cause it to send killer cells to help fight the tumor. The results, published in the journal Nature Communications, provide a basis for innovative cancer treatments. Mon, 29 May 2017 12:10:00 +0000 Cheat Sheet: How to Dry Solvents The G.I.T. Laboratory CheatSheet "How to Dry Solvents" provides you with information on the following topics:   Method Circulation Dryer Drying Agent Mon, 29 May 2017 12:02:00 +0000 Read & Win: Handbook of GC-MS Handbook of GC-MS Mon, 29 May 2017 11:03:00 +0000 Interview with Refika Bilgic, Chief Executive Officer (CEO) of IKA Works, on the development of the international lab market During Pittcon 2017 we had the chance to speak with Refika Bilgic, Chief Executive Officer (CEO) of IKA Works, about the development of the international lab market and the trade relations to the USA. Thu, 11 May 2017 06:50:00 +0000 Cost Effective Pipette Packs from Socorex The Triopack is a ready to use set including 3 Acura manual adjustable pipettes, sample of Qualitips, QC certificate and operating instructions. There are nine different Triopacks available, each covering specific volumes. The full coverage stretches between 0.1 µL to 10 mL. From molecular genetics to environmental analytics, this large choice of micropipettes offers convenient instrument combinations for any laboratory needs. Wed, 10 May 2017 10:22:00 +0000 The Importance of Tobacco Control In new research published today by King's College London - Institute of Cancer Policy and the Conflict & Health Research Group in the journal ecancermedicalscience, the difficulties of prioritising preventable disease and long term health issues in post conflict zones are explored. Fri, 28 Apr 2017 10:35:00 +0000 Stem Cells Re-Wired to Fight Arthritis? Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions. Such stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), develop into cartilage cells that produce a biologic anti-inflammatory drug that, ideally, will replace arthritic cartilage and simultaneously protect joints and other tissues from damage that occurs with chronic inflammation. Thu, 27 Apr 2017 15:20:00 +0000 Call for Papers: Global Challenges Special Issue on Interdisciplinary Research and Impact Global Challenges is inviting papers for a Special Issue on Interdisciplinary Research and Impact. Wed, 26 Apr 2017 12:14:00 +0000 Making Batteries from Waste Glass Bottles Researchers at the University of California, Riverside’s Bourns College of Engineering have used waste glass bottles and a low-cost chemical process to create nanosilicon anodes for high-performance lithium-ion batteries. The batteries will extend the range of electric vehicles and plug-in hybrid electric vehicles, and provide more power with fewer charges to personal electronics like cell phones and laptops. Fri, 21 Apr 2017 12:12:00 +0000 Nano-Sized Sensor: Feeling the Heat in Cells Tiny flat sensors that stick to the surface of living cells can provide detailed measurements of heat transfer at the cell surface. Developed at KAUST, these new sensors resolve some of the practical challenges of working with these tiny cells as well as enable novel diagnostic techniques. The results have been published in the journal Small. Wed, 19 Apr 2017 07:20:00 +0000