Laboratory Journal – Business Web for Users in Science and Industry en Heat-Not-Burn Tobacco vs E-Cigarettes If you haven't heard of heat-not-burn tobacco, you're not alone, but a new study published today in PLOS ONE from San Diego State University Graduate School of Public Health Associate Research Professor John W. Wed, 11 Oct 2017 18:04:00 +0000 Discover 5 ways to optimise lab efficiency  reduce chemical inventories and minimise costs, while making your laboratory a much safer place to work. Download the ebook to see how custom blends can add value to your business by saving time and reducing waste, while improving consistency, safety, and sustainability. Wed, 11 Oct 2017 08:00:00 +0000 Split or splitless: that is the question! The development in the field of stationary phases needed new system designs of the established HPLC hardware. In particular, the introduction of sub-2 µm particles required an enlargement of the back pressure capabilities as well as the minimization of all system- and dead volumes. That is why the gain in efficiency by using smaller particles is closely related to the pump technology as we would like to demonstrate in the following. Split or Splitless Mon, 09 Oct 2017 12:21:00 +0000 Labwise: Dynamic Image Analysis If one wants to, not only determine the size of the particles in powdered materials, but also learn something about their shape, dynamic image analysis is a method of choice. It facilitates taking measurements in both dry, free-flowing bulk solids and in a wet dispersion unit. Mon, 09 Oct 2017 07:07:00 +0000 CRISPR/Cas9 Protein Delivery Technologies The CRISPR/Cas9 system has emerged as a potentially game-changing tool for gene therapy. However efficient delivery of CRISPR components in mammalian cells is required for successful genomic editing. Different delivery formats with the ability to overcome issues connected with the use of viral, plasmid and RNA strategies have been developed, with protein-based CRISPR delivery being particularly promising. This review will cover advances in delivering Cas9 protein for gene editing.   Indroduction Fri, 06 Oct 2017 12:28:00 +0000 Molecular Scissors Revolutionize Plant Breeding The bacterial CRISPR/Cas system revolutionizes the possibilities of targeted genome modifications and thus enables unprecedented progress in plant breeding. The understanding of natural DNA repair mechanisms in combination with this highly specific, versatile and efficient molecular tool allows for both the precise introduction of mutations in DNA and targeted reshuffling of genomes. Such modifications of genetic information can no longer be distinguished from naturally occurring events. Fri, 06 Oct 2017 08:48:00 +0000 Chiral Amines in Total Synthesis: The Biocatalytic Approach Procedures for the efficient production of enantiopure amines are highly desired reactions in total synthesis in lab-scale as well for industrial applications. Recently several biocatalytic methods matured to a level that offers straightforward preparative formation of chiral amines. Fri, 06 Oct 2017 08:00:00 +0000 Analytics of Substances in Food Packaging Material Introduction Fri, 06 Oct 2017 06:44:00 +0000 Visualising Life in silico Programming a molecular biology experiment can be similar to playing Sudoku; both are simple if you're working with only a few molecules or a small grid, but they explode in complexity as they grow. Now, in a paper published on Oct. 3 in the Biophysical Journal, researchers at UConn Health's Virtual Cell Project ( have made it far easier for cell biologists to build complex biological models. Thu, 05 Oct 2017 12:31:00 +0000 Read & Win: Metallomics Metallomics can be defined as the comprehensive analysis of metals in cells, cell compartments, or a specific tissue type. Thu, 05 Oct 2017 09:01:00 +0000 Mass Spectrometry Jeevan Sharma1 and Claudia Birkemeyer1 Thu, 05 Oct 2017 07:43:00 +0000 Cheat Sheet: Agarose Gel Electrophoresis Method Standard Settings (DNA) The Principle Electro-Osmotic Flow (EOF) Take Note! Thu, 05 Oct 2017 05:57:00 +0000 Nobel Prize in Chemistry 2017: This are the Winners! The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2017 to Jacques Dubochet University of Lausanne, Switzerland Joachim Frank Columbia University, New York, USA and Richard Henderson MRC Laboratory of Molecular Biology, Cambridge, UK "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution" Wed, 04 Oct 2017 11:46:00 +0000 Messe München Acquires Lab Africa Messe München bolsters its portfolio with the future market of Africa. By taking over Lab Africa, it is acquiring the only laboratory and analytics trade fair in South Africa, which is part of the analytica trade fair network. The first Lab Africa under the banner of Messe München will take place in Johannesburg in mid-2019. Mon, 02 Oct 2017 13:39:00 +0000 Non-Native Species from Japanese Tsunami Aided by Unlikely Partner: Plastics A new study in Science reports the discovery of a startling new role of plastic marine debris -- the transport of non-native species in the world's oceans. Fri, 29 Sep 2017 05:11:00 +0000 Photometric color measurement In the past "colorimetry" was based on human color vision, which is strongly influenced by individual perception as well as by exterior influences, such as ambient light and the brightness. Only with the use of photometers and defined and standardized color systems, the subjective visual estimation was replaced with an objective and accurate measurement. This measurement procedure attempts to describe a color using one or more numeric values. In this whitepaper you learn which methods can be applied and what the applications are. Wed, 27 Sep 2017 13:55:00 +0000 Webinar: Inline Sample Preparation – An Effective Tool for Ion Chromatography Sample preparation in Ion Chromatography is connected to the chemical composition and the physical state of the sample at hand. Automating sample preparation can make IC even more accurate and efficient. Wed, 27 Sep 2017 12:06:00 +0000 Endress + Hauser acquire Moisture Measurement Company IMKO The Endress+Hauser Group is further enhancing its quality measurement portfolio through the acquisition of IMKO Micromodultechnik, a manufacturer of innovative moisture measurement systems. IMKO’s headquarters will remain in Ettlingen, Germany; the company’s 19 employees have been retained. Wed, 27 Sep 2017 10:30:00 +0000 "Mineral Plastic" The large usage of petroleum-based conventional plastics has incurred a lot of environmental issues, such as white pollution due to their non-degradability and costly recyclability. Nowadays, new plastic materials, which are environmentally friendly and bio-degradable, are calling for more and more attention. Meanwhile, the substituting plastic material should be cheap, easy to synthesize and recyclable while possessing comparable mechanical properties to conventional plastics. Wed, 27 Sep 2017 09:10:00 +0000 Amount of Water Influence Stem Cells Differentiation Adding or removing water from a stem cell can change the destiny of the cell, researchers have discovered in a new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS). The research found that altering the volume of a cell changed its internal dynamics, including the rigidness of the matrix lining the outer surface. In stem cells, removing water condenses the cell, influencing the stem cells to become stiff pre-bone cells, while adding water causes the cells to swell, forming soft pre-fat cells. Wed, 27 Sep 2017 09:08:00 +0000 Storing Information at the Molecular Level Around 1900, it became possible to store information on magnetic wires and tapes, and this development finally paved the way for modern day computers. With the advent of personal computers and related devices, such as mobile telephones, our world has become highly technology-oriented and data storage has become digitalized. One of the challenges in the highly technological world that we live in is saving large amounts of information in the digital form. Wed, 27 Sep 2017 08:50:00 +0000 Human Antibodies from Dengue Patients Effectively Treat Zika Infection in Mice Scientists have discovered that antibodies taken from patients infected with Dengue virus are effective in treating Zika infection in rodents. The team, led by researchers at Imperial College London and Washington University in St Louis, found that giving Zika-infected mice the antibodies was enough to treat the early stages of infection, and even protected unborn pups in pregnant animals. Wed, 27 Sep 2017 08:32:00 +0000 Focal Molography: Holograms for Molecules Scientists at ETH Zurich and Roche have developed a completely new method for the analysis of molecules in liquids on a chip. The possible applications of this technology are immense. It has the potential, inter alia, to revolutionise medical diagnostics. Much can be detected in blood or urine: viral illnesses, metabolic disorders or autoimmune diseases can be diagnosed with laboratory tests, for instance. But such examinations often take a few hours and are quite complex, which is why doctors hand the samples over to specialist laboratories. Tue, 26 Sep 2017 08:44:00 +0000 Ricin Only Lethal in Combination with Sugar Researchers at the Austrian Academy of Sciences’ Institute for Molecular Biotechnology (IMBA) have discovered a means of immunising cells against the biological weapon ricin, as reported in the current issue of Cell Research. Wed, 20 Sep 2017 07:46:00 +0000 Qualitix - New Pipette Tip Programme Socorex is pleased to announce the launch of its new Qualitix tip programme including an extended model selection covering most application requirements. Made from virgin Polypropylene, the DNAse, RNAse free, pyrogens/endotoxins and ATP free Qualitix provide for a very high purity degree. In addition, sterile tips are certified free of human DNA. Wed, 13 Sep 2017 06:45:00 +0000