Microfluidic Devices: Monitoring Cellular Oxygen Consumption
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Microfluidics devices fabricated from cyclic olefin copolymer (COC) and polydimethylsiloxane (PDMS) were combined with sensor foils to enable monitoring of oxygen tensions in the devices. The oxygen consumption of rat lung microvascular endothelial cells (EC) and rat hepatocytes (Hep) was numerically simulated and experimentally validated.
The Visisens (Presens Precision Sensing) system enables determining oxygen levels in the microfluidic devices and allows suggesting suitable culture device material depending on the application and cell line of interest. Furthermore, a previously characterized hypoxia microfluidic chip was evaluated and the system was found to exhibit superior sensing capabilities when compared to similar products.