Real-time Monitoring Using Compact Mass Spectrometry via LC/MS and Flow Injection/MS
Advion's Solution to Real-time Monitoring of a Suzuki Reaction
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Medicinal chemists are routinely faced with personally synthesizing over a hundred new chemical entities (NCE's) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route. TLC and LC/UV/MS are routinely used to monitor and guide these reaction outcomes. In most cases the LC/UV/MS technology is only available through a central core facility or via shared open access of systems. A preferred alternative is a personal small LC/CMS system located in a hood adjacent to the synthetic reaction apparatus. This note describes such an LC/CMS system used to monitor and optimize a Suzuki coupling reaction.