Real-time Monitoring Using Compact Mass Spectrometry via LC/MS and Flow Injection/MS

Advion's Solution to Real-time Monitoring of a Suzuki Reaction

  • Compact single quadrupole mass spectrometer for hood-based applicationsCompact single quadrupole mass spectrometer for hood-based applications
  • Compact single quadrupole mass spectrometer for hood-based applications
  • Suzuki reaction to prepare p-aminobiphenyl
  • LC/CMS Analysis of Suzuki reaction - results in 6 minutes
  • Fia/CMS of Suzuki reaction - results in 1 minute

Medicinal chemists are routinely faced with personally synthesizing over a hundred new chemical entities (NCE's) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route. TLC and LC/UV/MS are routinely used to monitor and guide these reaction outcomes. In most cases the LC/UV/MS technology is only available through a central core facility or via shared open access of systems. A preferred alternative is a personal small LC/CMS system located in a hood adjacent to the synthetic reaction apparatus. This note describes such an LC/CMS system used to monitor and optimize a Suzuki coupling reaction.

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CM20 2NQ Harlow
GB

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