Thin Layer Chromatography (TLC) - Online and Offline Coupling with Mass Spectrometry

  • Fig. 1: Extraction headFig. 1: Extraction head

TLC is a very fast, convenient and cost effective tool to get information about mixtures. This type of chromatography is a daily task in a synthesis laboratory and can be accomplished on the bench.

In most cases the chemist is interested in the identity of the separated compounds. Because of the limited amount of material which can be separated on an analytic TLC, mass spectrometry is the first choice to do this.

As an example the reaction mixture of a simple synthesis is controlled by TLC and the spots are characterized by online and offline MS methods.

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Camag AG
Sonnenmattstr. 11
4132 Muttenz
Switzerland

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