Identifying Environmental Pollutants - Metabolic Profiling of Accurate Mass LC-MS/MS Data

  • Fig. 1: Scores plot of PCA of more than 70 water samples indicating trends by sample comparison. Fig. 1: Scores plot of PCA of more than 70 water samples indicating trends by sample comparison.

Public concern that commonly used pharmaceuticals and personal care products (PPCP) are entering and contaminating the drinking water supply continues to rise. To address this concern, scientists use targeted quantitation of PPCP - a well established approach - but there is also an emerging trend to screen for and identify unexpected environmental pollutants.

Targeted Pollutants
In order to properly assess the effects of pharmaceuticals and personal care products on the environment, it is necessary to accurately monitor their presence (1). The diversity of chemical properties of these compounds makes method development challenging. Liquid Chromatographycoupled to tandem Mass Spectrometry (LCMS/MS) is able to analyze polar, semi-volatile, and thermally labile compounds, covering a wide molecular weight range, such as pesticides, antibiotics, drugs of abuse, x-ray contrast agents, drinking water disinfection by-products etc. In addition, state-of-the-art LC-MS/MS instruments operated in selective Multiple Reaction Monitoring (MRM) mode, offer unmatched selectivity and sensitivity to quantify PPCP reproducibly at trace levels without time consuming and extensive sample preparation (2).

Read more within the full pdf on the application of the AB Sciex TripleTOF 5600 LC/MS/MS System.

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