Diabetes Research: Pancreas Stem Cell Discovery May Lead to New Treatments
People with type 1 diabetes might one day be able to regenerate their own insulin-producing cells, researchers from the Walter and Eliza Hall Institute were able to identify stem cells in the adult pancreas that can be turned into insulin producing cells. They further provide evidence that stem cells don't only occur in the embryo.
The ability to produce the hormone insulin is crucial for controlling blood sugar (glucose) levels. In people with type 1 diabetes the body's immune system destroys the insulin-producing beta cells of the pancreas, leading to a potentially fatal elevation of blood glucose levels.
People with type 1 diabetes rely on multiple daily injections of insulin, or an insulin infusion pump, to control their blood glucose, but control is not perfect and they are at risk of serious long-term health complications.
Dr Ilia Banakh and Professor Len Harrison from the institute's Molecular Medicine division have not only identified and isolated stem cells from the adult pancreas, but developed a technique to drive these stem cells to become insulin-producing cells that can secrete insulin in response to glucose.
Professor Harrison said that insulin-producing cells had previously been generated from cells in the adult pancreas with ‘stem cell-like' properties. "But what Dr Banakh has done is pinpoint the cell of origin of the insulin-producing cells and shown that the number of these cells and their ability to turn into insulin-producing cells increases in response to pancreas injury. This is exciting, because it means that the potential to regenerate insulin-producing cells is there in all of us, even as adults," Professor Harrison said.
"In the long-term, we hope that people with type 1 diabetes might be able to regenerate their own insulin-producing cells. This would mean that they could make their own insulin and regain control of their blood glucose levels, curing their diabetes. Of course, this strategy will only work if we can devise ways to overcome the immune attack on the insulin-producing cells, that causes diabetes in the first place," Professor Harrison said.
Professor Harrison is a clinician scientist whose research led to current clinical trials that could prevent type 1 diabetes.
In recognition of his achievements, Diabetes Australia will tonight award Professor Harrison the Outstanding Contribution to Diabetes Award at its awards dinner marking World Diabetes Day.
The stem cell research, published this month in the journal Plos One, was supported by the JDRF, the National Health and Medical Research Council of Australia and the Victorian Government.
Ilia Banakh, Leonel J. Gonez, Robyn M. Sutherland, Gaetano Naselli, Leonard C. Harrison: Adult Pancreas Side Population Cells Expand after β Cell Injury and Are a Source of Insulin-Secreting Cells. Plos One, published on November 9, 2012