DNA Nanotechnology: Non-aqueous Solvent Supports DNA Technology
Who needs water to assemble DNA? Non-aqueous solvent supports DNA nanotechnology. Scientists around the world are using the programmability of DNA to assemble complex nanometer-scale structures. Until now, however, production of these artificial structures has been limited to water-based environments, because DNA naturally functions inside the watery environment of living cells.
Researchers at the Georgia Institute of Technology have now shown that they can assemble DNA nanostructures in a solvent containing no water. They also discovered that adding a small amount of water to their solvent increases the assembly rate and provides a new means for controlling the process. The solvent may also facilitate the production of more complex structures by reducing the problem of DNA becoming trapped in unintended structures.
The research could open up new applications for DNA nanotechnology, and help apply DNA technology to the fabrication of nanoscale semiconductor and plasmonic structures.
Read more within the original publication:
Isaac Gállego, et al.: Folding and Imaging of DNA Nanostructures in Anhydrous and Hydrated Deep-Eutectic Solvents, Angewandte Chemie International, 2015. doi/10.1002/anie.201412354