HIV: Key Mechanisms Elucidated in Men
Having suggested in 2011 that the urethra is a novel entry site for HIV, a team from the Institut Cochin (CNRS/Inserm/Université Paris Descartes, with the support of Anrs), has now confirmed this hypothesis and identified the cells and mechanisms brought into play : the immune system cells macrophages, present in the epithelium of the urethra, allow the entry of HIV. This work, published online on the website of the journal Mucosal Immunology, could make it possible to test novel HIV/AIDS prevention strategies.
Read more within the original publication:
Ganor Y. et al.: The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages. Mucosal Immunology, received 14 June 2012; accepted 17 October 2012; advance online publication 28 November 2012. doi:10.1038/mi.2012.116