Medical Diagnostic Tool: A Vibrational Spectroscopic Imaging Technology
- A new technology that could represent an advanced medical diagnostic tool for the early detection of cancer and other diseases is made possible with this electronic device developed at Purdue's Jonathan Amy Facility for Chemical Instrumentation in the Department of Chemistry. The device is called a 32-channel tuned amplifier array, or TAMP array. Two patents have been issued for the new technology. (Purdue University image)
A vibrational spectroscopic imaging technology that can take images of living cells could represent an advanced medical diagnostic tool for the early detection of cancer and other diseases.
High-speed spectroscopic imaging makes it possible to observe the quickly-changing metabolic processes inside living cells and to image large areas of tissue, making it possible to scan an entire organ.
"For example, we will be able to image the esophagus or urinary bladder for diagnosis of tumors," said Ji-Xin Cheng, a professor in Purdue University's Weldon School of Biomedical Engineering and Department of Chemistry. "If you were to take one millisecond per pixel, then it would take 10 minutes to obtain an image, and that's too slow to see what's happening in cells. Now we can take a complete scan in two seconds."
The technology represents a new way to use stimulated Raman scattering to perform microsecond-speed vibrational spectroscopic imaging, which can identify and track certain molecules by measuring their vibrational spectrum with a laser, a sort of spectral fingerprint.
Findings appeared on March 27 in the Nature Publishing Group journal Light: Science & Application.
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or within the original publication:
Liao, C-S et al.: Microsecond Scale Vibrational Spectroscopic Imaging by Multiplex Stimulated Raman Scattering Microscopy. Light: Science & Applications (2015) 4, e265; doi:10.1038/lsa.2015.38. Published online 27 March 2015