Just as efficient as analytical columns
In a recently published study, Hetzel et al. were able to prove that Micro-LC columns with an internal diameter of 300µm exhibit the same separating efficiency as classic HPLC-columns with an internal diameter of between 2.1mm and 4.6 mm. A long standing preconception that Micro-LC columns cannot be as well packed as the classic HPLC-columns could therefore be considered null and void. Having said that, critical system volumes that contribute to band broadening outside the separating column do have to be drastically reduced. The publication is available on request from the authors under firstname.lastname@example.org .
Original Publication: Hetzel et al., Journal of Separation Science 2016, 2016, DOI 10.1002/jssc.201600775.
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