New Four-Dimensional Separation and Detection System
In a recently published manuscript, Stephan et al. described the construction of a four-dimensional separation and detection system. The system consists of a two-dimensional HPLC, of ion mobility spectrometry (IMS) and of high resolution mass spectrometry. In contrast to the more comprehensive 2D-LC (LC x LC) a process is described where the modulation time is significantly increased (four minutes compared to <60 seconds). Due to the longer running time in D2, the peak capacity of the whole system can be increased significantly. In addition the data evaluation can be achieved more simply than that obtained from the comprehensive 2D-LC-Coupling. The system’s performance is demonstrated using the analysis of a plant extract (Ginkgo biloba).
Original Publication: Stephan et al., Analytical Bioanalytical Chemistry, 2016, 408, 3751-3759, DOI:10.1007/s00216-016-9460-9
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