Scientists Discover How Tension Changes the Structure of DNA
VU University: A team of researchers from VU University (led by Gijs Wuite and Erwin Peterman), together with colleagues from France and Singapore have discovered how mechanical tension changes the structure of DNA.
Advanced physics techniques show that the DNA structure can be disrupted in three distinct ways when the DNA molecule is stretched. The researchers propose that the ability to switch easily between three different structures may be important for genome regulation and stability. The results of the Dutch/French group and the Singaporean group are published back-to-back this week in the scientific journal Proceedings of the National Academy of Sciences (PNAS).
Read more within the original articles:
Graeme A. King, Peter Gross, Ulrich Bockelmann, Mauro Modesti, Gijs J. L. Wuite, and Erwin J. G. Peterman: Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy. Published online before print February 19, 2013, doi: 10.1073/pnas.1213676110. PNAS February 19, 2013 201213676
Xinghua Zhang, Hu Chen, Shimin Le, Ioulia Rouzina, Patrick S. Doyle and Jie Yan: Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry. Published online before print February 19, 2013, doi: 10.1073/pnas.1213740110. PNAS February 19, 2013 201213740