Dec. 15, 2011
NewsScientific News

Tireless Research Reveals Secrets of the Melatonin

A team from the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University has made a major breakthrough by unraveling the inner workings of melatonin, also known as the "sleep hormone." The research, conducted in collaboration with scientists in Italy, reveals the key role played by the melatonin receptor in the brain that promotes deep, restorative sleep.

This discovery led the researchers to develop a novel drug called UCM765, which selectively activates this receptor. The results, published in The Journal of Neuroscience, may pave the way for the development of new and promising treatments for insomnia, a common public health problem that affects millions of people worldwide.

Read more wothin the original publication:
Rafael Ochoa-Sanchez, Stefano Comai, Baptiste Lacoste, Francis Rodriguez Bambico, Sergio Dominguez-Lopez, Gilberto Spadoni, Silvia Rivara, Annalida Bedini, Debora Angeloni, Franco Fraschini, Marco Mor, Giorgio Tarzia, Laurent Descarries, and Gabriella Gobbi: Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2 Melatonin Receptor Ligand. The Journal of Neuroscience, 14 December 2011, 31(50): 18439-18452; doi: 10.1523/​JNEUROSCI.2676-11.2011

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