Laboratory Journal – Business Web for Users in Science and Industry en Researchers Discover Key Mechanism of DNA Replication Researchers from Osaka University in Japan have uncovered a key control mechanism of DNA replication with potential implications for better understanding how cells maintain genetic information to prevent diseases or cancer. Thu, 16 Aug 2018 12:54:00 +0000 Corporate Responsibility Sartorius, a leading international partner of the biopharmaceutical industry and the research sector, has been awarded for its responsible activities in the areas of environment, labor practices, ethics and sustainable procurement. Thu, 16 Aug 2018 12:25:00 +0000 Designing Nanocrystals for More Efficient Optoelectronics New artificial materials for semiconductors used in solar cells or photoelectrochemical cells that are designed from scratch with totally new and tailored properties: this is the latest research topic of Stefan Wippermann, head of the group “Atomistic Modelling“ at the Max-Planck-Institut für Eisenforschung, and his team. Thu, 16 Aug 2018 09:57:00 +0000 Molecular Switch Detects Metals in the Environment An international team, led by researchers from the University of Geneva (UNIGE), Switzerland, has designed a family of molecules capable of binding to metal ions present in its environment and providing an easily detectable light signal during binding. Wed, 15 Aug 2018 09:48:00 +0000 Rapid analysis of fentanyls and other novel psychoactive substances Drug overdose deaths due to fentanyls and other novel Tue, 14 Aug 2018 08:21:00 +0000 Another Step Forward on Universal Quantum Computer Yokohama, Japan. Researchers have demonstrated holonomic quantum gates under zero-magnetic field at room temperature, which will enable the realization of fast and fault-tolerant universal quantum computers. Mon, 13 Aug 2018 08:43:00 +0000 Mechanism of Fibrosis Development Discovered Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process. Now a group of scientists from Helmholtz Zentrum München working with colleagues from the University of Denver have taken a further step towards uncovering the mechanisms responsible for the development of fibrosis: IPF is associated with the increase of extracellular vesicles that relay WNT5A signals to cells in the lungs. Mon, 13 Aug 2018 08:06:00 +0000 Refractive Index Detector for Challenging GPC/SEC Applications The Differential Refractive Index (DRI) Detector from Testa Analytical Solutions is a next-generation instrument for challenging GPC/SEC applications. Thu, 09 Aug 2018 17:17:00 +0000 Sartorius: Exceptional researchers wanted! In March, the Grand Prize Winner and the three finalists of the 2017 Sartorius & Science Prize for Regenerative Medicine & Cell Therapy were ceremoniously presented with their awards during the Research Xchange Forum in Trends and Challenges on Regenerative Medicine & Cell Therapy. Wed, 08 Aug 2018 12:09:00 +0000 Reliable High-Throughput Flow Cytometry Device cleaning or the startup and shutdown of a flow cytometer are necessary, but also annoying processes that often cloud the fun of flow cytometry. These procedures take up time that the user could spend much more effectively doing something else. Learn in this application note how automated flow cytometers can manage these boring domestic tasks all by themselves. Tue, 07 Aug 2018 06:54:00 +0000 The Connection Matters The connection technique plays an important role when micro-LC columns are used instead of analytical HPLC columns. Just a few years ago, it was very difficult to get user-friendly “tools and accessories” that enable a simple and intuitive connection. At present, some suppliers offer user-friendly, biocompatible and high-pressure stable components to realize a low dead volume connection between the individual modules and the HPLC column. Mon, 06 Aug 2018 11:21:00 +0000 Artificial Intelligence Takes on Chemical Research A new tool is drastically changing the face of chemical research – artificial intelligence. In a new paper published in Nature, researchers review the rapid progress in machine learning for the chemical sciences. Mon, 06 Aug 2018 09:44:00 +0000 Read & Win: Integration of Omics Approaches and Systems Biology for Clinical Applications Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. Mon, 06 Aug 2018 08:34:00 +0000 Researchers Uncover Molecular Mechanisms of Rare Skin Disease Keratinocyte skin cells are common targets of the beta subtype of human papilloma virus. This usually harmless infection causes skin disease in people with rare gene mutations. You're probably infected with one or more subtypes of the human papilloma virus and, as alarming as that may sound, odds are you will never show any symptoms. The beta subtype of the virus, ß-HPV, is widespread in the general population and the least pathogenic; in fact, most carriers don't even know that they have it. Thu, 02 Aug 2018 09:30:00 +0000 Future Lab – The Automated Laboratory of the Future Classic analytical laboratories today still have a comparatively low degree of automation. However, increasing numbers of samples and increasing cost pressure also make automation indispensable in this area. The complexity of analytical processes with regard to the process steps and the required lab ware requires new concepts and approaches. Thu, 02 Aug 2018 06:00:00 +0000 Combining Two “Catalytic Worlds” Chemoenzymatic cascade reactions are quite recent, exciting reaction concepts, since they are able to combine benefits of two catalytic fields [1]. Chemoenzymatic cascades have been successfully used e.g. in the coupling of reactions with P450 monooxygenases or hydrolases and water-tolerant metathesis catalysts. The major challenge for the combination of such intrinsically distinct catalysis systems is the mutual compatibility of the catalysts themselves and of their reaction conditions. Wed, 01 Aug 2018 08:53:00 +0000 Selenium-based Lewis Acids In the field of homogeneous catalysis, an extensive number of transition metal-based catalysts are known. Though highly potent, they have critical drawbacks, like high costs or toxicity. Thus, the application of metal-free catalysts got in the focus of research during the last years. Wed, 01 Aug 2018 08:30:00 +0000 Hitachi High-Technologies launches the SU7000 Hitachi High-Technologies Corporation announced that it will launch the SU7000, a Schottky field emission scanning electron microscope (FE-SEM) that incorporates a large specimen chamber, enhanced versatility, and high throughput with simultaneous acquisition as well as analysis of various signal types. Tue, 31 Jul 2018 18:49:00 +0000 Insight into Nuclear Excitations A new mechanism for nuclear excitations via two-photon electron transitions is proposed and studied theoretically. Detailed calculations were performed for the E1E1 1s2s 1S0 → 1s2 1S0 two-photon decay of heliumlike 225Ac87+ ions and, especially, for the resonant excitation of the 3/2+ isomeric state at the energy 40.09(5) keV. The probability for such a two-photon decay via the nuclear excitation is found to be Tue, 31 Jul 2018 07:00:00 +0000 New Insights on Cancer Risks New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations is significantly elevated. These mutations arise because "typos" can occur as DNA replicates during cellular division. A recent analysis, which found that random mistakes in DNA play a large role in many cancer types, underscores the need to understand more about what triggers these errors. Tue, 31 Jul 2018 06:56:00 +0000 Extreme Conditions in Semiconductors Scientists from the University of Konstanz and Paderborn University have succeeded in producing and demonstrating what is known as Wannier-Stark localization for the first time. In doing so, the physicists managed to overcome obstacles that had so far been considered insurmountable in the field of optoelectronics and photonics. Mon, 30 Jul 2018 13:31:00 +0000 Drug Delivery System Targeting Senescent Cells Senescent cells are damaged cells that do not perform their normal roles anymore but that are not dead -hence they are commonly known as zombi cells. These cells interfere with the functioning of the tissue in which they accumulate. Fri, 27 Jul 2018 06:28:00 +0000 A New 'Periodic Table' For Nanomaterials The approach was developed by Daniel Packwood of Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and Taro Hitosugi of the Tokyo Institute of Technology. It involves connecting the chemical properties of molecules with the nanostructures that form as a result of their interaction. Mon, 23 Jul 2018 13:36:00 +0000 New Training Platform for Big Data Analysis Studies indicate that more than 95 per cent of researchers in the life sciences are already working with big data or plan to do so – but more than 65 per cent state that they only have minimal knowledge of bioinformatics and statistics. Fri, 20 Jul 2018 13:05:00 +0000 PhD Program in Cognitive Neuroscience – Calls Still Open The UniSR offers a PhD program in Cognitive Neuroscience aimed at the advanced training of graduates interested in understanding the neural processes underlying cognitive functions and behavior, both in normal conditions and in neurological and psychiatric diseases, working side-by-side not only with experts of the field, but also in dedicated laboratories with the most modern neurophysiological and neuroimaging methods. The areas proposed by the Doctorate will be: Thu, 19 Jul 2018 08:43:00 +0000