Aug. 06, 2018

Read & Win: Integration of Omics Approaches and Systems Biology for Clinical Applications

  • Integration of Omics Approaches and Systems Biology for Clinical ApplicationsIntegration of Omics Approaches and Systems Biology for Clinical Applications
  • Integration of Omics Approaches and Systems Biology for Clinical Applications
  • Antonia Vlahou
  • Fulvio Magni
  • Harald Mischak
  • Jerome Zoidakis

Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting.


Tonia Vlahou
is co-Director of the Proteomics Unit at Biomedical Research Foundation, Academy of Athens, Greece. She has been the Coordinator of the COST Action on ‘Kidney and Urine Proteomics’ and of the ITN program “Clinical and system –omics for the identification of the Molecular DEterminants of established Chronic Kidney Disease”. She also serves as external expert for biomarker qualification at the European Medicines Agency.

Fulvio Magni
is a Full Professor at the Faculty of Medicine and Surgery (Univ. Milano-Bicocca). He is a member of the Executive Committee of the Italian Mass Spectrometry division of the Italian Chemical Society (DSM-SCI). He is also a member of the Italian Society of Clinical Chemistry (SIBIOC) and of Biochemistry (SIB). He is an Associated Editor of the Journal of Integrated OMICS.

Harald Mischak
is the founder and director of Mosaiques Diagnostics. He initiated the use of urinary proteomics and CE-MS for clinical application, and is a leading authority in clinical proteomics and biomarker identification. He developed the guidelines for clinical proteome analysis, and successfully applied of proteomics in diagnosis and prognosis of several diseases.

Jerome Zoidakis
is a research scientist at the proteomics laboratory of the Biomedical Research Foundation, Academy of Athens.

He is actively involved in biomarker discovery and validation by mass spectrometry approaches, and integration of omics data. He is also teaching proteomics classes at the graduate level and has designed events for dissemination of scientific research results to a lay audience.


G.I.T.: What is your main focus in research, what is your main scientific interest?
Editors: The main focus of our research is to elucidate the molecular features of human diseases in order to identify novel therapeutic targets and biomarkers that could improve patient management. We have applied mass spectrometry based proteomics and multiomics data integration approaches in the context of Chronic Kidney Disease, Cardiovascular Disease, and Cancer.

G.I.T.: What was the reason to write the book?
Editors: This book presents state-of the art high throughput analytical approaches used to investigate biological samples with main focus on data integration in order to offer novel solutions to clinical needs. Currently, there are many different experimental approaches available and each of them provides an insight of the biological specimen from a different perspective (genomics, transcriptomics, proteomics, peptidomics, metabolomics). To fully exploit the information contained in these large datasets, novel bioinformatics tools are applied. The combination of classical and computational biology, has led to the development of a new discipline: systems biology. Its aim is to study biological entities globally (Holistic view) rather than concentrating on their particular aspects (Reductionist view). It was important to publish a book that illustrates clearly the available options for integration of omics datasets and how systems biology approaches can be used to elucidate the molecular basis of human diseases.

G.I.T.: What is the target audience for the book?
Editors: The target audience for the book covers a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, bioinformaticians working on the different molecular platforms (genomics, metabolomics, transcriptomics, MS-imaging, proteomics, peptidomics), clinicians; (under-graduate, graduate) students in the aforementioned fields.
What knowledge is prerequisite for the book?
Editors: A Bachelor in Sciences degree is the minimum prerequisite for reading this book.

G.I.T.: What is the structure of the book?
Editors: The book presents
a) an over-view of state of the art –omics techniques currently used to obtain the comprehensive molecular profile of biological specimens and
b) computational tools used for
i) databasing of these multi-source data and
ii) their integration towards developing molecular models for disease pathophysiology.
As test cases we present the investigation of chronic kidney disease (CKD) and bladder cancer.

G.I.T.: How close are omics approaches to becoming routine?
Editors: There are significant obstacles for routine application of omics approaches in the clinical setting. A major issue is the validation of robust analytical platforms.

G.I.T.: What will be – in your opinion - the “next big thing” in the field?
Editors: We foresee that multiomics data integration will allow efficient patient stratification according to molecular features and thus permit individualized therapeutic approaches.

G.I.T.: If you could advance one particular technology in the field, which one would it be?
Editors: The precise quantification of entire proteomes will allow characterization of the molecular phenotype. Such an approach is in its infancy but within the next 10 years it will be possible to achieve this ambitious goal.

Special promotion for our readers:
Use the Code GIT17 when ordering the book to receive a 30 % discount off the price.
This code is valid until 1st of June 2018.

Vlahou, A. et al. (ed.)
Integration of Omics Approaches and Systems Biology for Clinical Applications
Series: Wiley-Interscience Series on Mass Spectrometry
ISBN: 978-1-119-18114-9
Also available in electronic formats!

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