Science - Pharma & Drug Discovery | Laboratory Journal – Business Web for Users in Science and Industry - Business web for Users in Science and Industry

Jul. 26, 2010
SciencePharma & Drug Discovery
“Lab-on-Chip” Drug Discovery & Development
Many common problems of the drug discovery & development process can easily be addressed by microfluidic technology; it highly increases the potential of existing bioassays, chemical synthesis and separation technology. Our group is ...
Jul. 26, 2010
SciencePharma & Drug Discovery
Ultra-high Throughput Screening for Lipase Enantioselectivity
With modern molecular biology methods gene libraries can be generated that upon expression in a bacterial host may result in over 109 different enzyme variants. Using classical microtiter plate screening formats, only a tiny fraction, ...
Jul. 26, 2010
SciencePharma & Drug Discovery
High Content Screen Assay of Endosome Movement
Today, high content screens are performed mostly as end-point assays on fixed cells. With this kind of approach only static events can be described. But cells are in permanent dynamic equilibria. This dynamic state is necessary to respond ...
Jul. 23, 2010
SciencePharma & Drug Discovery
Enthalpy Arrays for Compound Screening
Enthalpy arrays enable label-free, solution-based calorimetric detection of molecular interactions in an array format [1-3]. The combination of the small size of the detectors and ability to perform measurements in parallel results in a ...
Jul. 23, 2010
SciencePharma & Drug Discovery
Screening for Allosteric Kinase Inhibitors in High Throughput
Kinases and their associated signaling pathways are largely responsible for the regulation of intracellular processes. Aberrantly regulated kinases can ultimately cause total cellular disregulation and contribute to the onset of several ...
Jul. 23, 2010
SciencePharma & Drug Discovery
The Good, the Bad and the Very Bad
Interest in cancer stem cells (CSC) continues to grow and we are now at a stage where a fundamental understanding of their mechanism of development and disease progression can be addressed [1]. Observations that solid tumors are typically ...
Jul. 23, 2010
SciencePharma & Drug Discovery
DNA-Encoded Chemical Libraries
The isolation of specific binding molecules is a central problem in the drug discovery process. Libraries of organic molecules, covalently coupled to DNA tags that serve as amplifiable identification bar codes, represent a new tool for the ...
Jul. 23, 2010
SciencePharma & Drug Discovery
Drug Delivery Markets
Drug delivery technologies are mechanism of transferring the desired drug into the body so as to reach the target site. The conventional forms of drug delivery are oral, injection and topical. However, the need for advanced forms of drug ...

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